Colchicine Flashcards
1
Q
Colchicine can be stored in a well lit room
A
False - need to shield from ultraviolet light
2
Q
Colchicine binds to dimers of tubulin, preventing assembly into microtubules
A
True
3
Q
Colchicine with its PMN suppression and anti mitotic activity, could be beneficial theoretically on both psoriasis and palmoplantar pustulosis
A
True
4
Q
Prolonged colchicine therapy has also be shown to halt progression in progressive systemic sclerosis
A
False
5
Q
Dose of colchicine is typically 1.2mg twice a day
A
False 0.6mg BD
6
Q
Colchicine overdose consists of which clinical features
A
- cholera like syndrome —> dehydration —> hyponatraemia —> metabolic acidosis —> renal failure - ultimately shock
7
Q
Other side effects of colchicine
A
Leukopaenia Aplastic anaemia Myopathy Alopecia Azoospermia Megaloblastic anaemia secondary to B12 malabsorption
8
Q
Monitoring guidelines
A
FBC, platelet count, serum urinalysis every 3 mo
