20. Systemic Retinoids Flashcards
Past q
Isotretinoin is 9-cis retinoids acid
F
13-cis retinoic acid
The primary form of dietary vitamin A in humans is retinyl ester
T
Retinal Ester is found in plants
F
Found in animal and meat products
Eggs and milk
Retinal in the 11-isomer and 11-trans isomer is important in the biochem reaction of visual function
T
Vitamin A cannot be synthesized in vivo by human body so must be acquired through diet
T
Past q
Acitretin is a poly aromatic retinoid
F: monoaromatic
Past q
High levels of retinoids are excreted in semen
F
Alcohol directly enhances re-esterification of acitretin to etretinate
F
Indirectly
What are the non aromatic retinoids ?
Tretinoin
Isotretinoin
Oral bioavailability of systemic retinoids increases with food
T
What are the mono aromatics retinoids ?
Etretinate
Acitretin
Poly aromatic retinoids are :
Alitretinoin
Tazarotene
Bexarotene
Adapalene
Isotretinoin and Acitretin are relatively water soluble
T
Acitretin is safer than etretinate for women of childbearing potential as etretinate is 50x more Lipophilic
T
Magnitude of hypertriglyceridaemia is greatest for Acitretin of all the retinoids
False
Bexarotene