Antimalarials

Question 1

Quinidine has an extra benzene ring and is considered an acridine compound

Answer 1

FALSE
quinaCRINE
Quinidine is an anti arrhythmic

Question 2

Antimalarials Are all water soluble

Answer 2

T

Question 3

Half life of Hcq and CQ is 40-50 hours

Answer 3

False

40-50 days

Question 4

Antimalarials have the highest concentration in bone , skin, and fat and the lowest in the liver , spleen and kidney tissues

Answer 4

F

Vice versa

Question 5

No dosage adjustment is required in pt with mild to moderate renal function impairment

Answer 5

T

Only 20% of unchanged HCQ eliminated by the kidneys

Question 6

MoA antimalarials

Answer 6

1- light filtration 
2- immunosuppressive effects
3- anti inflammatory effects
4- antiviral effects
5- inh platelet aggregation
6-  anti proliferative effects
7- reduction in Lipid and VitD levels

LIIVPPD

Question 7

Metabolites of HCQ are desethylchloroquine and desethylhydroxychloroquine

Answer 7

T

Question 8

Pregnancy and lactation is a relative CI in antimalarials as crosses placenta and excreted into Breast milk

Answer 8

T

Question 9

When taking antimalarials , ophthalmologist testing should occur at baseline and every 1-2 y for first five years

Answer 9

T

Question 10

Most antimalarials are substituted 4-aminoquinolones

Answer 10

True