IFN

Question 1

Interferon y has 29% structural homology to a

Answer 1

False

Question 2

Interferons do not cross placental barrier

Answer 2

T

Question 3

IFNa may interact with IL-2 to increase risk of haematological complications

Answer 3

F
This is its interaction with zidovudine

Int with IL-2 may increase renal failure
Int with aminophylline - decreased clearance possible via cyp1A2

Question 4

All interferons display anti viral activity

Answer 4

T

Question 5

IFN y has 30-70% abs su cut and IM

IFN a >80% subcut and Im

Answer 5

T

Question 6

IFN associated with hypotension

Answer 6

T

Question 7

IFN can be associated with development of antibodies in recombinant type

Answer 7

T

Question 8

IFN binds intracellularly

Answer 8

F

Binds specific surface receptors on target cells

Question 9

IFN are secretory glycoproteins

Answer 9

T

Question 10

IFN are non renally excreted

Answer 10

F

They are exceed by Kidneys

Question 11

IFN y is capable of enhancing /producing expression of class I or II MHC

Answer 11

F

This is action of IFN a and b

Question 12

There are increases in NK cell numbers and activity after exposure to IFNy

Answer 12

T

Question 13

IFNa and b are less potent stimulators of MHC antigens required for cellular immune reactions than IFNy

Answer 13

T

But note that they are capable of inducing exp of MHC 1 and 2 on immunocompetent and Tumor cells

Question 14

IFNa had been shown to inhibit angiogenesis

Answer 14

T

Question 15

IFNa may induce hypothyroidism

Answer 15

T