IVIG Flashcards
T/F
Peak serum levels of IVIG occur 2 hours after IV injection
False
Immediately after and are dose related
T/F
IVIG distributes itself throughout Intravascular (40%) and extra vascular (60%) space ,
Crosses placenta
May be excreted into milk
False
60% Intravascular
40% extra vascular
Remainder is true
T/F
IVIG contains supra physiologic levels of IgG and traces of other Ig
True
Half life of IVIG
3-5 weeks
IVIG mechanism of action
-1. Suppression of antibody production by binding via Fc fragment to corresponding cellular surface receptors on B lymphocytes – this may down regulate pathogenic autoantibody production
2. Block complement components C3&5 convertases , blocks complement activation at an early stage
3. Interfere with formation of terminal MAC
& inhibit auto reactive t
Lymphocytes
& modify local inflammatory response
& block keratinocytes apoptosis ?role
In TEN
IVIG counteracts the effects of steroids
F
Synergistic effect due to increased glucocorticoid receptor sensitivity
Synergistically suppress lymphocyte activation
Blood pressure changes and tachycardia can occur 30-60 mins post IVIG infusion
T
Anaphylaxis reported in patients with IgG deficiency due to anti IgG antibodies
F
IgA deficiency with auto IgA antibodies
Erythema nodosum has been reported as an AE Of IVIG
F
Em
Purpura
Alopecia dermatitis
Aseptic meningitis reported in up to 11% of neuro pt receiving IVIG
T
Haemorrhage has been reported following IVIG
F
Thromboembolic events
Slow down rate of infusion
Age and pregnancy status do not contraindicate use of IVIG
T
Ana needs to be tested prior to admin of IVIG
False
RF cryo globulins
Hep ABC
HIV
Ana needs to be tested prior to admin of IVIG
False
RF cryo globulins
Hep ABC
HIV
