TNF inhibitors Flashcards

1
Q

Infliximab inhibits membrane and soluble TNFa

A

T

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2
Q

Infliximab is of fully human origin

A

F
76% human
25% mouse

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3
Q

Adalimumab is an anti TNFa IgG

A

T

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4
Q

Infliximab half life 7 days

A

T

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5
Q

Development of anti drug antibodies are rare in Etanercept and Adalimumab

A

T

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6
Q

Psoriasis involved skin has decreased TNF-a compared to non lesional skin

A

False

More

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7
Q

Etanercept, infliximab and Adalimumab are Cat B

A

t

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8
Q

Etanercept is a dimeric fully human antibody

A

T

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9
Q

Concurrent administration of Etanercept , Adalimumab and infliximab with anakinra (IL-1 receptor antagonist) is a relative contraindication

A

False

Absolute contraindication

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10
Q

Etanercept does not influence levels of warfarin (Cyp2C9 pathway) or digoxin

A

T

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11
Q

MTX can decrease the clearance of adalimumab by 44%

A

T

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12
Q

Etanercept can be used in active Hepc

A

T

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13
Q

Concomitant use of TNF inh with IL-1 antagonists leads to increased risk of haematologic malignancies

A

F

Increased risk of serious infection

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14
Q

Increased risk of active tb infection with Etanercept > I & A

A

F
Other way around
I&a have higher rates than the fusion protein Etanercept

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15
Q

Inflimxiba contraindicated in CHF at doses above 5mg/kg

A

T

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16
Q

Concomitant admin of MTX w TNF inhibitors may increase incidence of auto drug Ab

A

False

Decrease

17
Q

Increased risk of active tb infection with Etanercept > I & A

A

F
Other way around
I&a have higher rates than the fusion protein Etanercept

18
Q

Inflimxiba contraindicated in CHF at doses above 5mg/kg

A

T