TNF inhibitors Flashcards
Infliximab inhibits membrane and soluble TNFa
T
Infliximab is of fully human origin
F
76% human
25% mouse
Adalimumab is an anti TNFa IgG
T
Infliximab half life 7 days
T
Development of anti drug antibodies are rare in Etanercept and Adalimumab
T
Psoriasis involved skin has decreased TNF-a compared to non lesional skin
False
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Etanercept, infliximab and Adalimumab are Cat B
t
Etanercept is a dimeric fully human antibody
T
Concurrent administration of Etanercept , Adalimumab and infliximab with anakinra (IL-1 receptor antagonist) is a relative contraindication
False
Absolute contraindication
Etanercept does not influence levels of warfarin (Cyp2C9 pathway) or digoxin
T
MTX can decrease the clearance of adalimumab by 44%
T
Etanercept can be used in active Hepc
T
Concomitant use of TNF inh with IL-1 antagonists leads to increased risk of haematologic malignancies
F
Increased risk of serious infection
Increased risk of active tb infection with Etanercept > I & A
F
Other way around
I&a have higher rates than the fusion protein Etanercept
Inflimxiba contraindicated in CHF at doses above 5mg/kg
T