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Pharmacology > Systemic Corticosteroids > Flashcards

Systemic Corticosteroids Flashcards

1
Q

Systemic corticosteroids increase secretion of gonadotropins and increase levels of testosterone in men and estrogen in women

A

False

Reduce

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2
Q

Systemic corticosteroids inhibit osteoprotegerin (osteoclastogenesis inhibitory factor)

A

T

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3
Q

Systemic corticosteroids promote bone loss by reducing calcium absorption and increasing renal calcium excretion

A

T

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4
Q

All endogenous and synthetic CS are well distributed into fetal tissue with exception of prednisone

A

T

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5
Q

The main carrier protein for CS is albumin

A

F

Cortisol binding globulin

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6
Q

CBG is decreased by hypothyroidism, liver disease, renal disease and obesity , increasing free fraction of CS

A

T

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7
Q

Exogenous CS is absorbed in the upper duodenum

A

F

Upper Jejunum

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8
Q

Prednisolone is preferable to prednisone in severe liver disease

A

T

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9
Q

Active form of cortisol is hydrocortisone

A

T

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10
Q

Hydrocortisone is formed through hepatic conversion of 11-ketone to 11-hydroxyl group by 11b hydroxysteroid dehydrogenase

A

T

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11
Q

In top steroids the MC effect is decreases by masking of the 16- or the 17- hydroxyl group with various ester links
Eg vale rate
Acetonide
Diproprionate

A

T

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12
Q

CS causes eosinophil and lymphocyte apoptosis

A

T

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13
Q

Cellular immunity > humoral immunity in CS

A

T

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14
Q

All endogenous and synthetic CS are well distributed into fetal tissue with exception of prednisone

A

T

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15
Q

The main carrier protein for CS is albumin

A

F

Cortisol binding globulin

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16
Q

CBG is decreased by hypothyroidism, liver disease, renal disease and obesity , increasing free fraction of CS

A

T

17
Q

Exogenous CS is absorbed in the upper duodenum

A

F

Upper Jejunum

18
Q

Prednisolone is preferable to prednisone in severe liver disease

A

T

19
Q

Active form of cortisol is hydrocortisone

A

T

20
Q

Hydrocortisone is formed through hepatic conversion of 11-ketone to 11-hydroxyl group by 11b hydroxysteroid dehydrogenase

A

T

21
Q

In top steroids the MC effect is decreases by masking of the 16- or the 17- hydroxyl group with various ester links
Eg vale rate
Acetonide
Diproprionate

A

T

22
Q

CS causes eosinophil and lymphocyte apoptosis

A

T

23
Q

Cellular immunity > humoral immunity in CS

A

T

24
Q

Addition of fluorine to hydrocortisone at 9a position leads to increased GC and decreased MC activity

A

F

Excessive MC ACTIVITY

25
Q

Peak secretion of cortisol is at 0800 pm

A

F

AM

26
Q

Liver disease may increase free fraction of CS As albumin decrease

A

T

27
Q

Alternate day dosing decreases risk of Osteoporosis cataracts and possibly osteonecrosis

A

F

No decrease in risk

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