Drugs for skinternist Flashcards
Bisphosphonates must be taken following an overnight fast and 30-60 mins before breakfast
T
Bisphosphonate oral abs occurs rapidly over approx 1 hour from upper Git
T
Active metabolite of fenofibrate is fenofibric acid
T
The terminal half life of alendronate is 10 y!
T
This reflects its slow release from bone
Bisphosphonates are incorporated into the bone matrix
T
Hypocalcaemia is a CI to BPp use
T
Hypercalc is an AE of bisphosphonates
F
Hypocalcaemia
What is the most common side effect of bisphosphates
Abdominal pain
What % of pt on Bexarotene develop hypothyroidism ?
70%!!
Fatigue and cold intolerance most common symptoms
T4 used in Bexarotene induced hypothyroidism is pregnancy cat A
T
Lovastatin should be taken without food and pravastatin with
F
Other way around
Statin bioavailability improved with admin of fenofibrate
T
Use of fibrate is warranted when element of hypertriglyceridaemia and hypercholesterolaemia
T
Fenofibrate may potentiate warfarin effects through inh cyp2c9
T
Fenofibrate dose must be adjusted in renal failure
T
Use of statins with gemfibrozil is contraindicated
T
Central hypothyroidism assoc with Bexarotene is reversible
T
Detrimental effects on immune system , CNS and bone have been attributed to statins
F
Beneficial
What is the role of Vit d in reducing CS induced osteoporosis mechanistically?
Vitamin d activates to 1,25 dihydroxyVitDbti regulate calcium and phosphorus concentrations leading to mineralization of skeleton to form strong bones and prevent osteoporosis
Which cancers has VitD reportedly had a role in preventing ?
Colorectal
Breast
Prostate
