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Pharmacology > Topical Antifungal Agents > Flashcards

Topical Antifungal Agents Flashcards

1
Q

Candida efficacy (based on MIC) in vitro

A

Ciclopirox = azoles > butenafine > naftifine > terbinafine

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2
Q

Most of azoles have demonstrated ability to inhibit chemo tactic ability of PMN
therefore anti inflammatory effects

A

True

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3
Q

In vitro anti dermatophyte potency

A

Butenafine>terbinafine>ciclopirox = naftidine > Azores

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4
Q

Nystatin is effective clinically and mycologically in treatment of cutaneous and mucocutaneous mycotic infections caused by Candida albicans

A

True

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5
Q

Azoles block biosynthesis of ergosterol by interfering with cytochrome P450 dependent enzyme , squalene epoxidase

A

False

14a demethylase but rest is true

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6
Q

Absorption of azole compounds is increased up to 4% on inflamed or damaged skin

A

True

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7
Q

Miconazole can be detected in stratum Corneum up to four days after single application

A

T

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8
Q

> 1% of miconazole is absorbed systemically

A

F

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9
Q

Miconazole has some activity against gram positive bacteria

A

True

Can be used to treAt erythrasma

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10
Q

Miconazole is a twice daily application except in tinea versicolor when it is once daily

A

True

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11
Q

Clotrimazole is used in oropharyngeal but not vaginal candidiasis

A

False

Used in both

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12
Q

Ketoconazole is water soluble with broad spectrum coverage of dermatophytes and yeast

A

True

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13
Q

Nystatin MoA

A

irreversible binding to cell membrane sterols causing cell leakage and permeability changes

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14
Q

Nystatin is a polyene antibiotic

A

True

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15
Q

Nystatin has some antibacterial activity

A

False

None

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16
Q

Nystatin is soluble in water so can be used on intact skin, GI tract or vagina

A

No
Water insoluble
Not used in these sites as not absorbed

17
Q

14a demethylase catalyses conversion of ergosterol to labosterol

A

False

Labosterol to ergosterol

18
Q

Miconazole is slightly water soluble

A

T

19
Q

Miconazole has some activity against gram positive bacteria

A

T

Has been modestly effective in erythrasma (corynebacterium = gram positive rod) impetigo and ecthyma

20
Q

Clotrimazole has some activity against gram positive bacteria

A

True

21
Q

Ketoconazole 2% cream is effective in treating cutaneous candidiasis and tinea versicolor

A

T

22
Q

Fungicidal concentrations of itraconazole are found in epidermis within 5 hours of application

A

T

23
Q

Econazole is a desamino derivative of miconazole

A

False

Deschloro derivative

24
Q

Econazole 1% cream is not as effective as clotrimazole 1% cream for treatment of tinea infections and cutaneous candidiasis

A

False
Equally effective
And more realistic onset of activity in pt treated with econazole

25
Q

Econazole has some gram positive and gram negative activity

A

True

26
Q

Ciclopirox olamine affects sterol biosynthesis as its MoA

A

False
Acts by interfering with active membrane transport of essential macromolecular precursors , disrupting cell memb integrity and inh enzymes essential for respiration

27
Q

Topical antifungals which do not contain propylene glycol

A 
Miconazole
Clotrimazole 
Econazole
Sertaconazole
Ciclopirox olamine
Selenium sulfide
28
Q

Clotrimazole coverage

A

Trichophyton
Epidermophyton
Microsporum
Candida (less than nystatin)

29
Q

Nystatin is effective in dermatophyte infection

A

F

Only candida

30
Q

Terbinafine is concentrated in sebum and hair follicles

A

T

Highly Lipophilic

Pharmacology (63 decks)

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