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Pharmacology > Topical Antibacterials For Acne And Rosacea > Flashcards

Topical Antibacterials For Acne And Rosacea Flashcards

1
Q

True/false

Benzoyl peroxide is Bactericidal and broad spectrum

A

T

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2
Q

True / false

Clindamycin is synthetic derivative of antibacterial agent lincomycin

A

T

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3
Q

T/F

Clindamycin binds reversibly to the 50s subunit of ribosomal RNA, inhibiting nucleic acid synthesis

A

False

Inhibiting protein synthesis

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4
Q

Clindamycin is Bactericidal and broad spectrum

A

True

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5
Q

Cross reactivity between sulfone and sulfonamide is uncommon

A

True

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6
Q

Twice daily application of 1% Clindamycin is as effective as oral minocycline 50mg twice daily

A

True

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7
Q

Azaleic acid inhibits division and differentiation of human keratinocytes but does not reduce the rate of sebum production

A

True

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8
Q

Azaleic acid is a tyrosinase inhibitor

A

True

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9
Q

Nystatin is a polyene antibiotic produced by Streptomyces noursei and Streptomyces albidus

A

T

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10
Q

Benzoyl peroxide coverage

A 
Propionibacterium Acnes 
Staph Capitis
S epidermidis
S hominis
Plasmodium ovale
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11
Q

Benzoyl peroxide commonly associated with contact allergy

A

F

Rare

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12
Q

Benzoyl peroxide antibacterial effects&raquo_space; keratolytic acne effects

A

True

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13
Q

Clindamycin Coverage

A

Bactericidal
SSBPP

s. Aureus
Streptococci
Bacteroides 
P. Acnes
Pneumococci
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14
Q

Erythromycin coverage

A 
G + cocci
Corynebacterium 
H. Influenzae
Legionella
Chlamydia
Treponema
Mycoplasma pneumoniae
Ureaplasma

CHICo+ MULT

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15
Q

Use of erythromycin in combo with BP is effective in reducing p.acnes resistance

A

T

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16
Q

Metronidazole is active against p. Acnes

A

F

Not active again p Acnes

17
Q

Topical dapsone is active against mycobacterium and pneumocystis jirovecii

A

T

18
Q

Antimicrobial activity of dapsone results from inhibition of dihydropteroate synthetase (enzyme that reduces folic acid)

A

T

19
Q

Sodium sulfacetamide coverage

A

P. Acnes

20
Q

There is rising resistance of p Acnes to benzoyl peroxide

A

False

Not encountered in vitro

21
Q

Sodium sulfacetamide produces an orange brown discoloration

A

True

Stains clothing but not skin

22
Q

Erythromycin 4% with 1.2% zinc can be effective in reducing erythromycin resistant p acnes in Vivo

A

T

23
Q

Metronidazole MoA

A

Synthetic nitroamidazole antibacterial readily taken up by anaerobic organisms
Reduction products of metronidazole disrupt DNA and inhibit nucleic acid synthesis

24
Q

Metronidazole coverage

A

BFVCPETGB

BACTEROIDES
FUSOBACT
VEILLONELLA
CLOSTRIDIUM
PEPTOCOCCUS
PEPTOSTREPTOCOCCUS
ENTAMOEBA HISTOLYTICA
TRICHOMONAS VAGINALIS
GUARDIA
BALANTIDIUM

not active against p.acnes, staph , strep, fungi or demodex

Pharmacology (63 decks)

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