Topical Antibacterials For Acne And Rosacea Flashcards
True/false
Benzoyl peroxide is Bactericidal and broad spectrum
T
True / false
Clindamycin is synthetic derivative of antibacterial agent lincomycin
T
T/F
Clindamycin binds reversibly to the 50s subunit of ribosomal RNA, inhibiting nucleic acid synthesis
False
Inhibiting protein synthesis
Clindamycin is Bactericidal and broad spectrum
True
Cross reactivity between sulfone and sulfonamide is uncommon
True
Twice daily application of 1% Clindamycin is as effective as oral minocycline 50mg twice daily
True
Azaleic acid inhibits division and differentiation of human keratinocytes but does not reduce the rate of sebum production
True
Azaleic acid is a tyrosinase inhibitor
True
Nystatin is a polyene antibiotic produced by Streptomyces noursei and Streptomyces albidus
T
Benzoyl peroxide coverage
Propionibacterium Acnes Staph Capitis S epidermidis S hominis Plasmodium ovale
Benzoyl peroxide commonly associated with contact allergy
F
Rare
Benzoyl peroxide antibacterial effects»_space; keratolytic acne effects
True
Clindamycin Coverage
Bactericidal
SSBPP
s. Aureus Streptococci Bacteroides P. Acnes Pneumococci
Erythromycin coverage
G + cocci Corynebacterium H. Influenzae Legionella Chlamydia Treponema Mycoplasma pneumoniae Ureaplasma
CHICo+ MULT
Use of erythromycin in combo with BP is effective in reducing p.acnes resistance
T
Metronidazole is active against p. Acnes
F
Not active again p Acnes
Topical dapsone is active against mycobacterium and pneumocystis jirovecii
T
Antimicrobial activity of dapsone results from inhibition of dihydropteroate synthetase (enzyme that reduces folic acid)
T
Sodium sulfacetamide coverage
P. Acnes
There is rising resistance of p Acnes to benzoyl peroxide
False
Not encountered in vitro
Sodium sulfacetamide produces an orange brown discoloration
True
Stains clothing but not skin
Erythromycin 4% with 1.2% zinc can be effective in reducing erythromycin resistant p acnes in Vivo
T
Metronidazole MoA
Synthetic nitroamidazole antibacterial readily taken up by anaerobic organisms
Reduction products of metronidazole disrupt DNA and inhibit nucleic acid synthesis
Metronidazole coverage
BFVCPETGB
BACTEROIDES FUSOBACT VEILLONELLA CLOSTRIDIUM PEPTOCOCCUS PEPTOSTREPTOCOCCUS ENTAMOEBA HISTOLYTICA TRICHOMONAS VAGINALIS GUARDIA BALANTIDIUM
not active against p.acnes, staph , strep, fungi or demodex
