Topic 57 Flashcards

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1
Q

Coat pigment synthesis

A

Melanocyte-stimulating hormone (MSH) attaches to MCH-R-receptors on melanocytes; Cause increase in tyrosinase enzyme activity; Create pigment synthesis in melaosomes: eu- and phaeomelanin produced

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2
Q

What creates various coat colours?

A

MSH-Receptor gene mutations of alleles at MSHR locus (E locus) create various coat colors.

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3
Q

Alleles are

A

E+, EsuperD, e

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4
Q

E+

A

normal, MSH dependent tyrosinase activity. Different -eu and phaeomelanin production; creare agouti colour

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5
Q

EsuperD

A

continuous tyrosinase activity; MSH binding not necessary; only eumelanin is produced; non agouti colour protein - black

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6
Q

e

A

low tyrosinase activity; red coat colour; only phaeomelanin produced

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7
Q

Pigment types

A

A, B, C, D, E, Indowhite, R

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8
Q

A

A

agouti (yellow/black)

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9
Q

B

A

brown (dun brown in Dexter cattle)

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10
Q

C

A

albino/no pigment

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11
Q

D

A

grey (blue in dog)

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12
Q

E

A

extension (red vs black)

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13
Q

Indowhite

A

palamino

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14
Q

R

A

roan

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15
Q

S

A

spotted

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16
Q

Albanism

A

gene defect causes tyrosinase activity inside melanocyte cells = disrupts melanocyte production causing no pigments to be created. Red eyes e.g. Hungarian Mudi pups