Test 4 Clinical Applications 2

Question 1

• Define:
  Bioengineered chimeric antibodies, they are a mix of mouse antibodies, with human tops of the Y.
• Treat:
  Cancer

Answer 1

Humanized Monoclonal Antibodies:

• Define:
• Treat:

Question 2

can Interleukin-2 and interferon be produced synthetically?

Answer 2

Yep.

Question 3

T-cells targeted for a melanoma are removed -> in vitro proliferation utilizing IL-2 -> Patient’s immune system suppressed by radiation -> Regulatory T cells inactivated -> T cells from harvest reintroduced.

Answer 3

Adoptive Cell Transfer:

Question 4

- Define:
Same as adoptive cell transfer.
Tumor infiltrating lymphocytes (t-cells) is what is being grown for reintroduction in adoptive cell transfer
- Treats:
Melonoma

Answer 4

Tumor-inflitrating lymphocyte therapy:

• Define:
• Treats:

Question 5

Patient’s own T cells given artificially created T-cell receptors specific to the tumor antigens

Answer 5

Chimeric antigen receptor (CAR) therapy: