Test 1 clinical applications/Investigations Flashcards
MMP stands for what?
What is the normal function of MMP:
Matrix metalloproteinases
Tissue remodeling (embryonic development and cell migration of phagocytic cells and other WBCs)
What stops matrix metalloproteinases from degrading intracellular proteins?
MMPs are activated extracellularly
How can MMPs contribute to disease?
What exists to stop these?
MMPs can contribute to disease by helping tumors metastasize and invade different locations. They can also contribute to disease if activated inappropriately.
MMPs are inhibited by
TIMPs
What are some generic examples of diseases that MMPs may be involved in?
Cancer migratino
Destruction of Cartilage protein in arthritis
Cardiovascular and neural disease (from an imbalance in TIMPs and MMPs)
Hemodialysis:
Peritoneal dialysis:
Hemodialysis: Blood is channeled to an external filtering system
Peritoneal dialysis: a dialysate is introduced into the peritoneal cavity, where the peritoneal membrane serves as the semipermeable membrane.
Dialysate:
Net diffusion of waste molecules from blood into the dialysate (the fluid it is diffused into)
What necessitates dialysis?
Inability of the kidney to filter (kidney/renal failure)
What are the symptoms of cystic fibrosis:
Excessively salty sweat, mucous build up in the pancreas and lung (promoting pancreatic and pulmonary disorders)
What is the molecular cause of cystic fibrosis:
A genetic defect in a glycoprotein known as CFTR (cystic fibrosis transmembrane conductance regulator) causes it to not be placed in the golgi complex for processing, and is incorrectly inserted into the plasma membrane
Are all cases of cystic fibrosis equally severe?
Is the disease curable/treateable?
Different mutations cause CFTR gene which can have cystic fibrosis of differing severity.
It is not curable but it is treatable.
Why are plasma proteins concentrated in the bloodstream?
What results if there is an abnormally low level of plasma proteins?
They cannot exit through the capillary pores, they are therefore osmotically active
The osmotic pressure from plasma proteins draws fluid from the interstitial fluid into the blood. Without this osmotic pressure edema occurs.
What underlying condition may cause there to be inadequate levels of protein in the blood and edema?
Cirrhosis of the liver can stop it from producing albumin. As albumin is osmotically active, it causes a drop in the osmolality of the blood and a flow of water into the interstitial fluid (edema)
What is in Ringer’s lactate:
Lactate, and Na, Cl, K, and Ca
Why is mannitol sometimes given intravenously to patients in the hospital?
Mannitol is osmotically active, and it will draw fluid out of other tissues. This can stop cerebral edema for example.
Why does hyperglycemia (as seen in diabetes mellitus) cause glycosuria
Sugar normally enters the urine and is pumped out by Na+/Glucose symport pumps. In patients with hyperglycemia these pumps become saturated and cannot pump out all the glucose in the urine.
Their transport maximum (Tm) is exceeded.
Why does hypoglycemia result in symptoms of the brain getting inadequate glucose?
Glucose transport into the brain, is a facilitated transport using GLUT1 and GLUT3 transporters, it relies on the concentration gradient.
What can cause severe hypoglycemia?
What results from severe hypoglycemia
Insulin overdose
Failure of glucose to diffuse into the brain. Loss of consciousness or death can ensue.