T Lymphocytes Flashcards
T lymphocyte development from fetal stages
Hematopoietic stem cell in fetal liver –> +34 progenitor –> Lymphoid progenitor —> migration of stem cell to thymus —> proliferation, differentiation, maturation
IL-7
most important cytokine for naive T cell survival
Most important cytokines for T cell development include
IL-1, IL-2, IL-6, IL- 7
Where do T cells go after migrating from the thymus?
kept in the peripheries without proliferating (much)
the number of mature T cells in the periphery remain constant in young adults, suggesting balanced loss of peripheral naive t cells
Ag receptors of T Cells
generated from rearrangement of multiple, inherited germline genes
After the production of Ag receptors for T cells, what is screened for?
T cells with highly self-reactive Ag receptors, they are destroyed
After the screening process, two kinds of T cells develop
Helper T Cells , which express CD4 and provide help for B cell growth and differentiation
Cytotoxic T lymphocytes (CTLs) express CD8 and recognize and kill virus infected cells
Functionally mature T cells migrate where?
to secondary lymphoid tissues
