Development of Lymphocytes Flashcards

1
Q

stem cells migrate, from where and to where?

A

Pluripotent stem cells in the fetal liver migrate to the thymus and bone marrow, which are referred to as the primary lymphoid organs

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2
Q

Primary Lymphoid organs include the

A

bone and thymus

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3
Q

T cells and B cells do what in primary lymphoid tissue?

A

they proliferate, differentiate, and mature

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4
Q

What kind of receptors are localized on the surface of T and B cells?

A

Ag-specific receptors

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5
Q

Naive lymphocytes have a shelf life of

A

1-3 months if they do not recognize an Ag

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6
Q

What defines a “resting lymphocyte” ?

A

it’s a naive lymphocyte that is not dividing, nor are they performing effector functions

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7
Q

What morphologically distinguishes a naive B and T cell?

A

they can’t be

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8
Q

naive lymphocytes receive a name when they are observed in blood smears. what?

A

small lymphocytes

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9
Q

resting lymphocytes occupy what stage in the cell cycle?

A

Go

they go on to enter G1 when stimulated before going on to divide

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10
Q

What functional difference is there between a large and small lymphocyte?

A

Larger lymphocytes are activated: their diameter is a little wider. They are called lymphocytes or lymphoblasts.

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11
Q

Survival of naive lymphocytes relies on signals produced by

A

Ag receptors and cytokines

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12
Q

Ag receptors of B cells =

A

BCR

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13
Q

Ag receptors of T cells =

A

TCR

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14
Q

A theory of B cell survival states that

A

BCRs stimulate survival signals even in the absence of Ag

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15
Q

How do naive T lymphocytes survive?

A

Naive T lymphocytes recognize Self Ag weakly: this generates survival signals but without triggering clonal expansion and differentiation into effector cells

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16
Q

IL-7

A

the most important cytokine for naive T cell survival: it promotes low level cycling of naive T cells

17
Q

BAFF

A

B cell-activating factor, required for B cell survival

BAFF = a cytokine belonging to the tumor necrosis family