Lymphocytes (general)

Question 1

Lymphocytes develop from _____ and then mature in

Answer 1

bone marrow stem cells and then mature in generative lymphoid organs

Question 2

Secondary lymphoid organs include the

Answer 2

spleen, lymph nodes, regional lymphoid tissues like mucosa-associated lymphoid tissues

Question 3

Lymphocytes circulate in the blood in order to reach different parts of the body. The exceptions include the

Answer 3

eye, brain, and testicles

Question 4

Lymphocytes circulate until they reach:

Answer 4

lymph nodes, skin, and intestine via specialized endothelium of postcapillary venules called High Endothelium Venule (HEV)

Question 5

HEVs

Answer 5

High endothelial venules, much higher than normal endothelial cells

HEVs expression high levels of cell adhesion molecules that serve as homing receptors for lymphocytes

Question 6

Lymphocytes migrate into tissues. What chemical and process are occurring?

Answer 6

Chemokines cause them to migrate via a process called diapedesis

Question 7

lymphocytes re-enter circulation through

Answer 7

efferent lymph vessels that converge into the thoracic duct

Question 8

Naive lymphocytes re-circulation

Answer 8

they can respond to antigens in the secondary lymphoid organs, or return to circulation through lymphatic drainage to the blood, where they can go to another secondary lymphoid organ

Question 9

Steps in lymphocyte activation: step 1

Answer 9

Fully mature naive T cells and immature B cells migrate into secondary lymphoid organs such as lymph nodes and spleen

Question 10

Steps in lymphocyte activation: step 2

Answer 10

B cells complete their maturation in LNs and spleen

Question 11

Steps in lymphocyte activation: step 3

Answer 11

Naive B and T cells activated by Ags differentiate into effector or memory lymphocytes

Question 12

Steps in lymphocyte activation: step 4

Answer 12

Some effector and memory cells migrate into peripheral tissues where active infection is occurring

Question 13

Steps in lymphocyte activation: step 5

Answer 13

Abs secreted by effector B cells in LNs, spleen, and bone marrow, enter the blood and are delivered to sites of infection