Selectins and Selectin Ligands

Question 1

P-Selectin

Answer 1

CD62P

endothelium activated by histamine or thrombin

Ligand is a Sialyl Lewis X on PSGL-1 and other glycoptoeins on neutrophils, monocytes, T cells (effector, memory cells)

Question 2

E selectin

Answer 2

CD62E

endothelium activated by cytokines TNF, IL-1

Ligands: Sialyl Lewis X (i.e CLA-1) on neutrophils, monocytes, T cells (effector, memory)

Question 3

L selectin

Answer 3

neutrophils, monocytes, T cells (naive and central memory), B cells (naive)

Sialyl Lewis X/PNaD on GlyCAM-1, CD34, MadCAM-1 on endothelium (HEV)

activated by IL-1 and TNF at sites of inflammation

Question 4

CD62P, CD62E

Answer 4

P selectin and E selectin

Question 5

IL-1 triggers

Answer 5

E-selectin expression on endothelial surface

IL-1 produced by tissue macrophages

Question 6

TNF triggers

Answer 6

E selectin

produced by tissue macrophages

Question 7

sialylated carbohydrates

Answer 7

related to Lewis X or Lewis family

ligands for the P and E selectins

Question 8

L selectins

Answer 8

ONLY expressed on leukocytes and lymphocytes

activated by TNG and IL-1 @ sites of inflammation

important for T/B lymphocytes homing into LNs via HEVs

Question 9

Molecules that interact on T/B lymphocytes and HEVs during homing

Answer 9

L selectins on T/B lymphocytes, and peripheral node addressins (PNads) on HEVs