Dendritic Cells Flashcards
Dendritic cells are the most
important APC in linking innate and adaptive immunity, as it is the most important APC in the immune system
Dendritic cells are the most important for activating
NAIVE T cells
DCs have what morphological qualities
long membranous processes and phagocytic capabilities
DCs arise from the
myeloid lineage, and a precursor that monocytes also arise from
The cytokine responsible for maturing dendrites is
Flt3 ligand, which binds to the Flt3 tyrosine kinase receptor on the precursor cell
Flt3 Ligand
the cytokine initiating dendritic cell maturation, it binds to the Flt3 tyrosine kinase receptor on the cell precursor surface
Macrophages and DCs express
surface receptors that recognize antigens typically made by microbes and not mammalian cells
DCs have
surface receptors that recognize Antigens made by microbes, and secretes cytokines
Process of DC development
Bone marrow Hematopoietic stem cell —> Monocyte/Dendritic cell precursor —> common dendritic cell precursor —> Pre classical DC and Plasmacytoid DC
pre-clas —> classical DC
Plasmacytoid —> plasmacytoid
Fetal hemapoietic organs —>
Embryonic tissue precursor —> Langerhans (skin macrophage)
Monocyte —> (during inflammation)
Inflammatory DC
Classical DCs (where)
largely reside in skin, mucosa, and parenchyma.
Classical DCs (activation)
after activation they migrate to LNs where they display Ags to T lymphocytes
Plasmacytoid DCs: definition
early cellular responders to viral infection
Plasmacytoid DC: target molecule and cytokine secretion
Ag = nucleic acids of intracellular viruses
produce soluble proteins type 1 inferferons aka IFN-alpha/beta
