B lymphocytes

Question 1

B cells develop from stem cells around what time in gestation?

Answer 1

14 weeks

Question 2

Differentiation of B cells occurs in the

Answer 2

fetal liver; after birth, in the bone marrow

Question 3

B cells have contact with a certain kind of cell, and specific cytokines in order to develop

Answer 3

Stromal cells

IL-1
IL-6
IL-7

IL-2 IS EXCLUSIVE TO T CELLS!!!!!!!!!

Question 4

discuss how B cell receptors are encoded (where, how, purpose)

Answer 4

In the bone marrow, B cell precursors rearrange germline genes that encode for B cell receptors, allowing them to be more Ag specific

BCR = Abs

Question 5

BCR =

Answer 5

Abs

Question 6

The problem is that some BCRs recognize self-Ags. How does the immune system deal with this conundrum?

Answer 6

B cells that possess BCR that recognize Self-Ag are eliminated

Question 7

Two kinds of B cells develop

Answer 7

B1 and B2, each with different properties

Question 8

_______ is the first antibody expressed on B cells as _______ followed by co-expression of _______

Answer 8

IgM, BCRs, IgD

Question 9

Mature B cells migrate into

Answer 9

secondary lymphoid tissues where they respond to Ag

Question 10

Where and how do B cells proliferate into plasma cells and memory cells?

Answer 10

In secondary lymphoid tissue

They’re stimulated by the specific antigen their BCR corresponds to, and in most cases with help from T cells

then they proliferate in germinal centers

Question 11

Plasma cells are what, and do what?

Answer 11

terminally differentiated B cells that produce and secrete large amounts of Ag

Question 12

A key step in the cooperation of T cells and B cells is

Answer 12

B cells present antigens to helper T cells

Question 13

Lymphocytes develop from ______ but mature in the

Answer 13

bone marrow stem cells

lymphoid organs