Circulation of Immune Cells

Question 1

Immune cells are _____ ______ that _____ ______

Answer 1

soluble components that constantly circulate through blood, into tissues, and back into blood

Question 2

At sites of infection or tissue injury, what is a key function of endothelial cells?

Answer 2

they’re activated by cytokines secreted by

1. macrophages
2. mast cells

Question 3

activation of endothelial cells is via

Answer 3

cytokines released by macrophages and mast cells at sites of infection or injury

Question 4

The function of activated endothelial cells is

Answer 4

increased adhesiveness for circulating myeloid leukocytes and Ag-activated effector and memory lymphocytes

Question 5

During “homing” the leukocytes/lymphocytes possess __________ and endothelial cells possess ______

Answer 5

L/L = chemokine receptors+homing receptors

Endothelial cells = chemokines

Question 6

addressins =

Answer 6

comprise a set of several adhesion molecules on the surface of endothelial cells which regulate lymphocyte recirculation of HEV