Molecules involved in migration of Naive and Effector T cells

Question 1

Ligand for receptor, location, and function of receptor

L selectin

Answer 1

Naive

pnAD

initial weak adhesion of naive T cells to HEVs in lymph nodes

Question 2

Ligand for receptor, location, and function of receptor

CCR7

Answer 2

Naive

CCL19 and CCL21

activation of integrins and chemokinesis

Question 3

Ligand for receptor, location, and function of receptor

LFA-1 (beta-2 integrin)

Answer 3

Naive

ICAM-1

stable arrest on high endothelial venule in lymph node

Question 4

Ligand for receptor, location, and function of receptor

E and P selectin ligands

Answer 4

acctivated (effector and memory) T cells

E or P selectin

initial weak adhesion of effector/memory T cell to endothelium and peripheral site of infection

Question 5

Ligand for receptor, location, and function of receptor

CXCR3

Answer 5

activated

CXCL10

activation of integrins and chemokinesis

Question 6

Ligand for receptor, location, and function of receptor

CCR5

Answer 6

activated

CCL4

acation of integrins and chemokinesis

Question 7

Ligand for receptor, location, and function of receptor

LFA-1
VLA-4

Answer 7

activated

ICAM-1 or VCAM-1

stable arrest on cytokine-activated endothelium @ peripheral site of infection