NLR family Flashcards
1
Q
NLRs recognize
A
intracellular crystals, ATP concentration changes, ions from damaged lysosomes
2
Q
NLRs are located
A
in the cytosol of phagocytes, epithelial cells, and other cells
3
Q
the secreted form of IL-1beta and IL-18 are
A
PRODUCED in the INFLAMMASOME
they are proinflammatory cytokinses
4
Q
The NLRP subfamily
A
14 NOD like receptors
respond to cytosolid PAMPS and DAMPs
5
Q
What is an inflammasome?
A
complex formed through NLRP recruited caspase-1
6
Q
caspase-1
A
cleaves the precursor form of IL-1B and IL-18
