Immature b cells pathway to the spleen Flashcards
1
Q
mechanism B cells use to home to secondary lymphoid tissue
A
exactly the same as T cells
2
Q
immature b cell pathway to speen
A
leave bone marrow, enter blood, circulate to spleen, enter red pulp, then migrate to periphery of white pulp
3
Q
as B cells mature, they express what molecule?
A
chemokine receptor CXCR5, which promotes movement into the white pulp in response to CXCL13
4
Q
what the spleen does, basically
A
immature B cells enter them, complete their maturation, and then re-enter circulation and home to lymph nodes and mucosal lymphoid tissues
