Innate Lymphoid Cells Flashcards
1
Q
develop from where
A
a common bone marrow precursor identified by the Id2 transcription factor
2
Q
Id2
A
Id2 transcription factor associated with Innate Lymphoid cell precursor
3
Q
3 major subsets of Innate lymphoid cells are distinguished how?
what are they
A
expression of distinct transcription factors, and cytokines produced
ILC1 –> IL-12 and IL-18
ILC2 –> IL-25 and IL-33
ILC3 –> IL-1 and IL-23
4
Q
ILC1 secretes IL12 and IL18 to stimulate release of
A
IFN gamma in response to viruses
5
Q
ILC2 secretes ____ and ____ and ____ to stimulate release of
A
IL-25, IL-33, TSLP to produce IL5 and IL 22 to produce an allergic reaction
6
Q
ILC3 secretes
A
IL-1 and IL 23 to stimulate release IL-1 and IL-22
in intestines, lymphoid organogenesis
