Scavenger Receptors

Question 1

SR family (define)

Answer 1

trimeric complexes of type II transmembrane polypeptides

Question 2

three regions on the SR

Answer 2

has three distinct extracellular regions

1. SR cysteine rich SRCR domain (absent in SR-II)
2. Collagen like domain, which is implicated in binding of polyanionic ligands
3. alpha helical coiled coil domain (absent in MARCO): which is believed to assist in receptor trimerization

Question 3

SRs do what?

Answer 3

mediate uptake of oxidized lipoproteins into the cell

Question 4

SR-A and CD36

Answer 4

expressed on macrophages, mediate recognition/phagocytosis of microorganisms

Question 5

CD36

Answer 5

functions as a corereceptor in TLR2/6 recognition and response to liptecichoic acid and diacylated lipoporteins

Question 6

SRs bind

Answer 6

various bacterial constituents based on negative charges of bacterial lipopolysaccharides, lipoteichoic acid, nucleic acids, beta-glucan, and proteins

Question 7

SRs KO mice show what symptoms

Answer 7

increased susceptibility to infection with several pathogens