Integrins

Question 1

LFA-1

Answer 1

CD11aCD18

Expressed on neutrophils, monocytes, T cells (Effector and memory), B cells (naive)

ligand is ICAM-1 and ICAM-2

Question 2

Mac-1

Answer 2

neutrophils, monocytes, dendritic cells

ICAM-1 and ICAM-2

Question 3

ICAM-1 and ICAM-2

Answer 3

CD54 and CD102, endothelium (cytokine induced)

Question 4

VLA-4

Answer 4

monocytes, T cells (naive, effector, memory)

Ligand: VCAM-1 (cytokine induced)

Question 5

alpha-4-beta-7

Answer 5

monocytes, T cells (gut homing, naive, effector, memory), B cells (gut homing)

Ligands: VCAM-1, MadCAM-1 (endothelium in gut and gut associated lymphoid tissues

Question 6

Integrins are

Answer 6

heterodimeric cell surface proteins that are non-covalently linked polypeptide chains

Question 7

Integrin activation causes what character about the integrins?

Answer 7

increases affinity for ligands

Question 8

Integrin activation occurs in which leurkocytes?

Answer 8

all of them + lymphocytes

Question 9

Integrin activation occurs in response to

Answer 9

in leukocytes, chemokine binding to chemokine receptors

in T lymphocytes, in response to Ag binding to TCRs

Question 10

how do chemokines influence integrins?

Answer 10

they induce a conformation change in the extracellular domain of the integrin: leading to increased affinity

Question 11

“inside out signaling” ?

Answer 11

the conformational changed in the ECD of the integrins leading to increased affinity

chemokine related