NLRP Subfamily and Inflammasome

Question 1

NLRP

Answer 1

(pryin-domain-containing proteins)

subfamily of 14 NOD like receptors

respond to cytosolic PAMPS and DAMPs by binding proteins and forming signaling complexes called inflammasomes

inflammasomes activate the enzume caspase-1 (a protease with cysteine residue in the active site)

Question 2

caspase-1

Answer 2

a protease with a cysteine residue in the active site

ckeaves inactive cytoplasmic precursor forms of two homologous cytokines IL-1beta and IL-18

Question 3

IL-1beta and IL-18

Answer 3

proinflammatory cytokines: secreted form is produced in the inflammasome