C-Type Lectin Families

Question 1

Macrophage mannose receptor

Answer 1

MMR and DEC-205

cysteine rich N terminal domain

a fibronectin like domain

multiple calcium dependent (C-type) lectin domains that bind various carbohydrate ligands

Question 2

C type lectin family all contain

Answer 2

a conserved carbohydrate recognition domain for microbial mannose, n acetyleglucosamine, and beta-glucans

Question 3

Distinguish between Eukaryotic cell carbohydrates an those on microbes

Answer 3

Eukaryotic end in galactose or sialic acid, most often; microbes end in mannose, L-fucose, and N-acetyl-glucosamine sugars

Question 4

What do these receptors do exactly

Answer 4

facilitate the phagocytosis of microbes and secretion of cytokines that promote subsequent immune responses

Question 5

What form do lectins appear as in the body?

Answer 5

both blood soluble and in the ECM, as well as integral membrane proteins on the surface of macrophages, dendritic cells, and some tissue cells