Rolling and Arrest of Effector T Lymphocytes

Question 1

CD44

Answer 1

important for mobilization of effector T cells in sites of infection and inflammation

Question 2

At endothelial inflammation sites, some molecules expressed include

Answer 2

P/R selectin, chemokines, and hyaluronic acid

Question 3

CD44 does what exactly

Answer 3

mediates rolling interactions with endothelial cells that express HA, its natural ligand

Question 4

Inside out signaling is induced by

Answer 4

signaling via GPCR, increasing integrin affinity for VLA-4

Question 5

CD44 + HA triggers

Answer 5

GPCR-dependent inside out upregulating of VLA-4-VCAM binding