Scavenger Receptors (SRs)

Question 1

SRs is a group of receptors who do what?

Answer 1

mediate uptake of oxidized lipoproteins into cells

Question 2

SRs receptors SR-A and CD36

Answer 2

expressed on macrophages and mediate recognition of/phagocytosis of microorganisms

Question 3

SRs CD36

Answer 3

can doubly function as a coreceptor in TLR2/6 recognition and response to bacterially derived lipteichoic acid an diacylated lipoproteins

Question 4

SRs do what exactly

Answer 4

bind various bacterial constituents based on NEGATIVE CHARGES of bacterial LPS (gram negative bac) lipoteichoic acid (gram positive bac) nucleic acids, b-glucans, and proteins

Question 5

SRs have three distinct ECM domains. What are they

Answer 5

1. SRCR: SR cysteine rich domain (absent in SR-A II)
2. Collagen like domain: which is implicated in the binding of polyanionic ligands
3. alpha helical coiled coil domain, believed to assist in receptor trimerization