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MSK > Systemic Lupus Erythematosus > Flashcards

Systemic Lupus Erythematosus Flashcards

1
Q

Who is more commonly affected by SLE?

A

Women

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2
Q

Which races are more commonly affected by SLE?

A

Afro-Caribbeans* and Asian communities

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3
Q

At what age does SLE usually tend present?

A

20-40 years

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4
Q

What type of condition is SLE?

A

Multisystem Autoimmune disease
Type 3 hypersensitivity reaction

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5
Q

What type of hypersensitivity reaction is SLE?

A

Type 3 hypersensitivity disease

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6
Q

What genes is SLE associated with?

A

HLA B8
HLA DR2
HLA DR3

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7
Q

What are the main general features of SLE?

A

fatigue
fever
mouth ulcers
lymphadenopathy

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8
Q

How can the skin be affected in someone with SLE?

A

Malar (butterfly) rash
Discoid rash
Photosensitivity
Raynaud’s phenomenon
Livedo reticularis
Non-scarring alopecia

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9
Q

What does the malar rash spare in someone with SLE?

A

The nasolabial folds

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10
Q

How does the discoid rash present in someone with SLE?

A

Scaly, erythematous, well demarcated rash in sun-exposed areas

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11
Q

What MSK symptoms can present in someone with SLE?

A

Arthralgia
Non-erosive arthritis

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12
Q

What cardiovascular symptoms can present in someone with SLE?

A

pericarditis (more common)
myocarditis

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13
Q

What respiratory symptoms can present in someone with SLE?

A

Pleurisy
Fibrosing alveolitis

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14
Q

What renal symptoms can present in someone with SLE?

A

Proteinuria
Glomerulonephritis

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15
Q

What neuropsychiatric symptoms can present in somene with SLE?

A

Anxiety and depression
Psychosis
Seizures

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16
Q

What antibodies are commonly present in someone presenting with SLE?

A

ANA
Anti-dsDNA
Anti-Smith

17
Q

What is the problem with using ANA for the diagnosis of SLE?

A

They are highly sensitive but have low specificity

18
Q

What is the most useful antibody for diagnosing SLE?

A

Anti-dsDNA

19
Q

What can be used to monitor SLE?

A

Inflammatory markers
complement levels (C3, C4)

20
Q

What inflammatory marker is used to monitor disease activity in SLE?

A

ESR

CRP- if raised suspect infection

21
Q

During active disease, would the complement levels be low or high in SLE?

A

Complement levels would be low during active disease

22
Q

What is the medical management of SLE?

A

Hydroxychloroquine

23
Q

What else can be used to manage SLE?

A

NSAID’s
Sun cream

24
Q

What is a serious complication of SLE?

A

Lupus nephritis

MSK (79 decks)

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