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MSK > Ankylosing Spondylitis > Flashcards

Ankylosing Spondylitis Flashcards

1
Q

What is Ankylosing spondylitis?

A

Inflammatory condition that mainly affects the spine

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2
Q

What group of conditions is ankylosing spondylitis part of?

A

Seronegative spondyloarthropathy group of conditions

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3
Q

What gene is associated with ankylosing spondylitis?

A

HLA B27

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4
Q

What joints are typically affected by ankylosing spondylitis?

A
  • Sacroiliac joint

* Joints of vertebral column

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5
Q

What is a characteristic feature of ankylosing spondylitis?

A

Bamboo spine

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6
Q

Who does ankylosing spondylitis usually affect?

A

Young adults

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7
Q

How long do symptoms take to develop in ankylosing spondylitis?

A

3 months

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8
Q

How does ankylosing spondylitis present?

A
  • Lower back and stiffness
  • Improves with movement
  • May wake them from sleep
  • Sacroiliac pain-in buttock region
  • Flares of worsening symptoms
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9
Q

What causes the symptoms in ankylosing spondylitis?

A

Inflammation causing pain and stiffness in the joints which cause fusion of the spine and sacroiliac joints

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10
Q

What is the main way that ankylosing spondylitis is diagnosed?

A

X-ray

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11
Q

What would you see on an x-ray of ankylosing spondylitis?

A
  • Syndesmophytes (bony growths can cause fusion of joint)
  • Squaring of the lumbar vertebrae
  • ‘Bamboo spine’
  • Sacroiliitis (inflammation of the pelvis)
  • Subchondral sclerosis (thickening of the bone)
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12
Q

What will schoberg’s test show in ankylosing spondylitis?

A

Reduced flexion

Reduced lordosis

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13
Q

What would you find in an MRI in Ankylosing spondylitis?

A

Romanus lesions in the bone marrow

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14
Q

What are the A features of Ankylosing Spondylitis?

A
  • Apical fibrosis- upper zone
  • Anterior uveitis
  • Aortic regurgitation
  • Achilles tendonitis
  • AV node block
  • Amyloidosis
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15
Q

What is the first line management of ankylosing spondylitis?

A

NSAID’s

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16
Q

What would you use to control the flares of ankylosing spondylitis?

A

Steroids

17
Q

What is an Anti-TNF used to control in ankylosing spondylitis?

A

Disease activity

18
Q

What Anti-TNF is used to manage disease activity in ankylosing spondylitis?

A

Infliximab

19
Q

What is the criteria for using Anti-TNF’s in ankylosing spondylitis?

A

Use in axial ankylosing spondylitis that has failed on 2 different NSAIDS and meets criteria for active disease on 2 occasions 12 weeks apart

20
Q

Who is more commonly affected by ankylosing spondylitis?

A

Young (20-30)
Males (3x)

21
Q

How is chest expansion affected in someone with ankylosing spndylitis?

A

It is reduced

22
Q

What non-pharmacological treatments are essential for people with AS to maintian mobility?

A

Exercise and physiotherapy

23
Q

What needs to be prescribed along with an NSAID?

A

PPI

24
Q

What do DMARD’s not do?

A

They do not improve spinal inflammation

MSK (79 decks)

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