Sjogren's Syndrome Flashcards
What is Sjogren’s syndrome?
Lymphocytic infiltration of exocrine gland
What exocrine glands are mostly affected in Sjogren’s syndrome?
Lacrimal
Salivary
What is Primary Sjogren’s syndrome?
It occurs alone
What is secondary sjogren’s syndrome?
It occurs secondary to connective tissue disease such as SLE or RA
What type of condition is Sjogren’s syndrome?
Chronic inflammatory autoimmune disease
What antibodies are present in Sjogren’s syndrome?
Anti-Ro
Anti- La
How does Sjogren’s syndrome present?
• Reduced salivation-Dry mouth
• Reduced tear production-Dry eyes
• Arthralgia
• Parotid gland enlargement
• Vaginal dryness and reduced GI secretions
How is Sjogren’s diagnosed?
• Antibodies
• Schirmer’s test
• Rose Bengal staining
Which anti-body is more specific to Sjogren’s syndrome?
Anti-Ro anti-body
What is the function of Schirmer’s test?
Testing conjunctival dryness
What is the function of Rose Bengal staining?
Keratitis (corenal inflammation)
What is there an increased risk of with Sjogren’s syndrome?
Non-Hodgkin’s Lymphoma
What is the management of ocular symptoms
Hypromellose (artificial tears)
What would you use to delay progression?
Hydroxychloroquine
What conditions can Sjogren’s syndrome occur secondary to?
SLE
RA
