SLE: Lupus nephritis Flashcards
What is lupus nephritis?
A severe manifestation of systemic lupus erythematosus
What can lupus nephritis result in?
End-stage renal disease
What should be monitored in patients with SLE?
Urinalysis-Rule out proteinuria.
How is lupis nephritis classified?
WHO classification
What is class 1 of the WHO classification of lupus nephritis?
Normal kidney
What is class 2 of the WHO classification of lupus nephritis?
Mesangial glomerulonephritis
What is class 3 of the WHO classification of lupus nephritis?
Focal (and segmental) proliferative glomerulonephritis
What is class 4 of the WHO classification of lupus nephritis?
Diffuse proliferative glomerulonephritis
What is class 5 of the WHO classification of lupus nephritis?
Diffuse membranous glomerulonephritis
What is class 6 of the WHO classification of lupus nephritis?
Sclerosing glomerulonephritis
What is the most common and severe form of lupus nephritis?
Class IV- diffuse proliferative glomerulonephritis
How does diffuse proliferative glomerulonephritis present?
Glomeruli shows endothelial and mesangial proliferation, ‘wire-loop’ appearance
What can occur if the diffuse proliferative glomerulonephritis is severe?
The capillary wall may be thickened secondary to immune complex deposition
What might you see on an electron microscope of diffuse proliferative glomerulonephritis?
Subendothelial immune complex deposits
What might you see with immunofluoresence of diffuse proliferative glomerulonephritis?
Granular appearance on immunofluorescence
