Synapses and Sensory Receptors Flashcards
junction
btwn synaptic terminal and naother neuron or effector
electrical synapses
electrical current flows from one neuron to another; no neurotransmitters
chemical synapses
synaptic cleft; presynaptic neuron AP arrives at synaptic terminal depolarizes pm VG channels open Ca2+ diffuse into terminal inc Ca2+ causes synaptic vessicals to fuse w terminal mem NT released into cleft and diffuse across + bind to specific receptors on postsyn mem
synaptic cleft
gap which seperates presynaptic neurons from postsynaptic cells (20nm)
presynaptic neuron
synthesizes NT; packaged into synaptic vessicles
acetylcholine
muscles, memory, learning NT
glutamate
excitatory NT
dopamine
mood NT
endorphins
pain regulation NT
ligand gated ion channels
graded potential in postsyn; mem of postsyn cell receptor protein binds + responds to NT (ligand) opens LG channels ions diffuse across postsyn mem; postsyn potential: EPSP (mem depolarizes) and IPSE (mem hyperpolarizes)
postsynaptic neuron
some EPSE some IPSP; dendrites + cell body recieve info from many chem synapses
magnitude of PSP varies based on
amnt of NT released by prosyn neuron; distance of synapse: one single EPSE has to travel to axon hillock may be too small to trigger AP
temporal summation of postsyn potential
2 EPSP @ single synapse right after each other; interplay btwn IPSP + EPSP axon hillock integrates, mem pot = summed efect, AP threshold
spacial summation of postsyn potential
EPSPs @ same time from diff syns on same postsyn; interplay btwn IPSP + EPSP axon hillock integrates, mem pot = summed efect, AP threshold
NS embryonic dev
overal structure: regulated gene expression, signal transduction; brain continues to develop + remodel: competition amongst neurons for growth supporting factors, synapse elimination