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DRUG OF THE DAY > Spironolactone > Flashcards

Spironolactone Flashcards

1
Q

Drug Class

A

aldosterone receptor antagonist

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2
Q

Common Indications

A 
Oedema 
Ascites 
Nephrotic Syndrome
Heart Failure 
Resistant Hypertension
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3
Q

Mechanism of Action

A

aldosterone receptor antagonist so less Na absorption thru ENaC (more Na/water leaves) & less K excretion thru ROMK in principal cells of CD

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4
Q

Adverse Effects

A

Hyperkalaemia

Gynaecomastia (androgen effects to increase breast size)

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5
Q

Contraindications

A

Hyperkalaemia - use alpha/beta blockers for hypertension instead
Pregnancy - centrally acting (labetalol) decrease symp outflow
Addisons

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6
Q

Drug Interactions

A

drugs that increase potassium (monitor)

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