Clopidogrel Flashcards
1
Q
Drug Class
A
ADP receptor antagonist
2
Q
Common Indications
A
prevention of thromboembolic events e.g. post MI, AF & stroke
3
Q
Mechanism of Action
A
irreversible inhibits binding of ADP to P2Y2 receptor to inhibit activation of GPIIb/IIIa receptors (independent of COX pathway)
pro drug - active hepatic metabolites
4
Q
Adverse Effects
A
bleeding!
GI upset- dyspepsia and diarrhoea
rarely- thrombocytopenia
5
Q
Drug Interactions
A
CYP inhibitors e.g. omeprazole, ciprofloxacin, erythromycin & some SSRIs
caution with other antiplatelet/anticoagulant/NSAIDs (bleeding risk)
needs stopping 7 days prior surgery
might need other PPIs with use
