Apixaban

Question 1

Drug Class

Answer 1

Direct Acting Oral Anticoagulants

Question 2

Common Indications

Answer 2

venous thromboembolism (DVT/PE)

Question 3

Mechanism of Action

Answer 3

direct Xa inhibitor (free/bound with ATIII)

do not directly effect thrombin (IIa)

Question 4

Adverse Effects

Answer 4

bleeding (but less monitoring needed)

Question 5

Contraindications

Answer 5

v low creatinine clearance (<15mL/min)

avoid in pregnancy & breastfeeding

Question 6

Drug Interactions

Answer 6

plasma conc:
increased by macrolides
decreased by carbamazepine, phenytoin & barbiturates

antidotes now available (andexanet)