Co-amoxiclav Flashcards
1
Q
Drug Class
A
penicillin group of beta-lactam antibiotics
2
Q
Common Indications
A
infections due to beta-lactamase-producing strains (where amoxicillin alone not appropriate), including respiratory tract infections, bone and joint infections, genito-urinary and abdominal infections
3
Q
Mechanism of Action
A
beta-lactam = bactericidal & interferes with synthesis of bacteria cell wall peptidoglycan
clavulanic acid = beta-lactamASE inhibitor so combined with amoxicillin resistant
4
Q
Adverse Effects
A
NVD
thrombocytopenia
hypersensitivity
skin reactions
5
Q
Drug Interactions
A
warfarin
methotrexate
oral contraceptives (as oral antibiotics can eliminate gut flora so lessen EnteroHepatic Recycling & lower conc with increased risk of pregnancy)
