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DRUG OF THE DAY > Azathioprine > Flashcards

Azathioprine Flashcards

1
Q

Drug Class

A

DMARDs

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2
Q

Common Indications

A

SLE, Vasculitis, IBD, bullous skin disease, atopic dermatitis & steroid sparing asthma

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3
Q

Mechanism of Action

A

cleaved to 6-MP —> TIMP —> 6-MeMPN (inhibit purine synthesis)

so antimetabolite decreases DNA & RNA synthesis

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4
Q

Adverse Effects

A

Myelosupression (monitor FBC)
increased risk of malignancy & infection
hepatitis (monitor LFT)

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5
Q

Drug Interactions

A

other immunosuppressants

ACEi/ARBs

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DRUG OF THE DAY (27 decks)

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