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DRUG OF THE DAY > Atorvastatin > Flashcards

Atorvastatin Flashcards

1
Q

Drug Class

A

Statin

more efficacious & off patent compared to simvastatin

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2
Q

Indications

A

hyperlipidaemia
prevent CVS events

(higher dose for secondary prevention-CVS event)

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3
Q

Mechanism of Action

A

competitive inhibition of HMG-CoA reductase & upregulates hepatic LDLr & increased LDL clearance

REDUCE CVD risk by:
improve vascular endothelial function (more NO&VEGF/less endothelin)
stabilise atherosclerotic plaque (less SMC prolif & more collagen)
improve haemostasis (less fibrinogen&aggregation/more fibrinolysis)
anti-inflammatory (less CRP&adhesion&cytokines)
antioxidant (less superoxide form)

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4
Q

Adverse Effects

A

GI disrupt, nausea & headache
myalgia (as more CPK but dose related)
rarely rhabdomyolysis
increased liver enzymes

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5
Q

Contraindications

A

renal or hepatic impairment
pregnancy
breastfeeding

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6
Q

Drug Interactions

A

CYP 3A4
(amiodarone/diltiazem/macrolides/amlodipine/GRAPEFRUIT JUICE increase statin)

might need to withhold statin temporarily whilst other agents taken

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DRUG OF THE DAY (27 decks)

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