Sitagliptin Flashcards
1
Q
Drug Class
A
Dipeptidyl Peptidase-4 (DPP-4) inhibitor
gliptin
2
Q
Common Indications
A
Type 2 Diabetes Mellitus
3
Q
Mechanism of Action
A
prevents incretin degradation so increased plasma levels
glucose dependent so postprandial action doesn’t stimulate insulin secretion at normal glucose level - lower hypoglycaemic risk
suppress appetite so weight neutral
4
Q
Adverse Effects
A
GI upset pancreatitis risk (1%)
5
Q
Contraindications
A
pregnancy
history of pancreatitis
6
Q
Drug Interactions
A
other hypoglycaemic agents
drugs that increase glucose can oppose action-thiazide/loop diuretics
