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DRUG OF THE DAY > Aspirin > Flashcards

Aspirin Flashcards

1
Q

Drug Class

A

cyclo oxygenase inhibitor

NSAID/antiplatelet

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2
Q

Common Indications

A

AF
secondary prevention of stroke/TIA/ACS
post primary PCI & stent
often with other antiplatelet agents
NSTEMI/STEMI - initial (once) 300mg loading dose chewable
acute ischaemic stroke - initial 300mg daily 2 weeks

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3
Q

Mechanism of Action

A

irreversibly inhibits COX1 mediated production of thromboxane A2 (potent platelet aggregator formed from arachidonic acid by CIX1)

action at low non analgesic doses (75mg) - higher inhibit endothelial prostacyclin PGI2

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4
Q

Adverse Effects

A

GI irritation/bleeding (peptic ulcer)
haemorrhage (stroke)
hypersensitivity

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5
Q

Contraindications

A

Reyes Syndrome (avoid under 16yrs)
hypersensitivity
3rd trimester can premature close ductus arteriosus

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6
Q

Drug Interactions

A

other antiplatelet & anticoagulant as additive/synergistic action

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DRUG OF THE DAY (27 decks)

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