Metformin Flashcards
1
Q
Drug Class
A
Biguinade
oral hypoglycaemic agent
2
Q
Common Indications
A
Type 2 Diabetes Mellitus
3
Q
Mechanism of Action
A
inhibit gluconeogenesis to decrease hepatic glucose production
(but some activity so less hypoglycaemic risk)
suppress appetite to limit weight gain
4
Q
Adverse Effects
A
GI upset - nausea, vomiting & diarrhoea
so modified release can be given
5
Q
Contraindications
A
eGFR<30mL/min
alcohol intoxication
as excreted unchanged by kidneys
6
Q
Drug Interactions
A
drugs that may impair renal function - ACEi, NSAIDs & diuretics
diuretics (loop/thiazides) also increase glucose so can reduce metformin action
