LMWH Flashcards
1
Q
Drug Class
A
anticoagulant
2
Q
Common Indications
A
VTE prevention/initial treatment
ACS short term
(does not cross placenta so use in pregnancy)
3
Q
Mechanism of Action
A
inhibition of Xa specifically by enhancing ATIII activity
4
Q
Adverse Effects
A
bruising & bleeding (intracranial/at injection site/GI/epistaxis)
Heparin Induce Thrombocytopenia
hyperkalaemia
osteoporosis
5
Q
Contraindications
A
clotting disorder
renal impairment
6
Q
Drug Interactions
A
other antithrombotics
ACEi/ARBs + spirinolactone
less monitoring (aPTT) as predictable but can be reversed with protamine sulphate (no effect on fondaparinux)
