Self Tolerance & TRegs Flashcards
A T cell activates to self antigens during initial development in the thymus. What are the possible outcomes for this T cell?
Apoptosis or Treg development
How do the mechanisms against self-reactive T cells in peripheral tolerance differ from central tolerance?
In central tolerance, self-reactive T cells undergo apoptosis or development into Tregs. In peripheral resistance, they undergo anergy, apoptosis, or release immune inhibitory signals
What types of lymphocytes are eliminated/inactivated via peripheral tolerance?
Mature lymphocytes - only immature lymphocytes are destroyed in central tolerance
True/False. A B Cell that is stimulated by a self antigen is automatically eliminated.
False. B cells, unlike T cells, can undergo receptor editing. If the B cell is still activated after editing, only then will it be eliminated.
What inhibitory receptors are located on T cells?
CTLA-4 & PD-1
A non-self antigen that induces an immune response is termed…?
Immunogenic
What CD receptors are expressed on Tregs?
CD4 & CD25
What mechanisms are used by Tregs to supress the immune response?
Release TGFb & IL-10, express CTLA-4, consumes IL-2
What is Foxp3?
Transcription factor of Tregs
A self antigen that induces immune tolerance is termed…?
Tolerogenic
What co-stimulatory interaction is required to activate a T cell?
CD28-B7
A mature lymphocyte that activates by a self antigen undergoes apoptosis. What is this process termed?
Peripheral tolerance
What is the function of IL-2?
Stimulates T-cell proliferation
What anti-inflammatory cytokines are released by Tregs to suppress the immune response?
IL-10 & TGFb
B7 binds what inhibitory receptor on T cells?
CTLA-4
