Pathology of Hepatitis

Question 1

What rash is associated with HBV?

Answer 1

Polyarteritis nodosa

Question 2

What alleles are associated with autoimmune hepatitis?

Answer 2

DR3 & DRB1

Question 3

Epithelioid granulomas are histological findings associated with what liver infections?

Answer 3

Fungal and mycobacteria infections of the liver

Question 4

Identify. Slide from acute hepatitis infection.

Answer 4

Acidophilic body - remnants of apoptotic hepatocytes

Question 5

In chronic hepatitis infection, inflammatory cells move from the portal system into hepatocytes. What is this process called?

Answer 5

Interface activity

Question 6

What characterizes type 2 autoimmune hepatitis?

Answer 6

Anti-liver kidney microsome-1 (LKM-1) & anti-liver cytosol (ACL-1) antibodies

Question 7

This parasitic infection of the liver increases the risk of cholangiocarcinoma.

Answer 7

Liver flukes

Question 8

Hepatocytes with a “ground-glass” appearance are associated with what chronic hepatitis infection?

Answer 8

HBV

Question 9

There are two types of autoimmune hepatitis. Which type is more common in children?

Answer 9

Type 2 autoimmune hepatitis

Question 10

What characterizes type 1 autoimmune hepatitis?

Answer 10

Antinuclear antibodies (ANAs) & anti-smooth muscle actin (SMA) antibodies

Question 11

What immune cells are primarily present in acute hepatitis?

Answer 11

Lymphocytes and pigmented macrophages

Question 12

What finding is most associated with echinococcosis infection of the liver?

Answer 12

Hydatid cysts

Question 13

What is ascending cholangitis?

Answer 13

Bacterial infection of the biliary tree often due to biliary obstruction

Question 14

Lymphoid follicles are associated with what chronic hepatitis infection?

Answer 14

HCV

Question 15

What type of autoimmune hepatitis is most common?

Answer 15

Type 1 - generally in women < 40yo

Question 16

As adjacent hepatocytes die, bands of connective tissue are formed. What is this called?

Answer 16

Bridging Necrosis