Pharmacology of Anti-Parasitic Drugs Flashcards
What is the MOA of albendazole and mebendazole?
Bind to beta-tubulin to prevent tubulin polymerization and glucose uptake
This antiparasitic drug is the drug of choice for nematode infections, cystic hydatid disease, and neurocysticercosis.
Albendazole
This drug inhibits tubulin polymerization and is contraindicated in children due to the risk of convulsions.
Mebendazole
What is the MOA of ivermectin?
Stimulates glutamate-controlled Cl- channels to cause Cl- influx, hyperpolarization, and paralysis.
Mazotti reactions are associated with which antiparasitic drug?
Ivermectin & Diethylcarbamazine (more severe reactions)
What is the clinical use of ivermectin?
River blindness, strongyloidiasis
True/False. Ivermectin may be used in pregnancy.
False - pregnancy is a contraindication
This antiparasitic stimulates nicotinic receptors to cause depolarization-induced paralysis.
Pyrantel pamoate
What are the clinical uses for pyrantel pamoate?
Hookworms, roundworms, pinworm alternative
This antiparasitic is used to treat filariasis, but may cause life-threatening Mazzotti reactions.
Diethylcarbamazine (DEC)
What is the MOA of praziquantel?
Increases membrane permeability to Ca2+, causing contraction and subsequent paralysis
Praziquantel is contraindicated in treating what disease?
Ocular cysticercosis
What are the clinical uses for Praziquantel?
Cestode infections, alternative to albendazole for neurocysticercosis
This antiparasitic is known to cause disulfiram-like reactions and should not be combined with alcohol.
Metronidazole
What are the clinical indications for metronidazole and tinidazole?
Trichomoniasis, giardiasis
What drugs are used to treat luminal amebic infections?
Diloxanide furoate, iodoquinol, paromomycin
What drugs are used to treat leishmaniasis?
Milteforsine, Stibogluconate
