Pharmacology of Diarrhea, Constipation, IBS & IBD Agent

Question 1

This class of drugs are used for IBD acute flares.

Answer 1

Corticosteroids (prednisone)

Question 2

These drugs are indicated to treat IBS-constipation and activate Cl- channels.

Answer 2

Lubiprostone, linaclotide

Question 3

What is the MOA of Natalizumab?

Answer 3

Anti-integrin that prevents leukocyte binding to vascular endothelium

Question 4

What are the clinical indications for alosetron?

Answer 4

Women with refractory IBS-diarrhea. Efficacy has not been established in men.

Question 5

This anti-diarrheal is a 5-HT3 receptor antagonist.

Answer 5

Alosetron

Question 6

What is the MOA of magnesium hydroxide?

Answer 6

Osmotic agent that increases the water content of stool to treat constipation

Question 7

True/False. Methylnaltrexone is a first-line anti-diarrheal. for opioid-induced constipation.

Answer 7

False - methylnaltrexone is an opioid antagonist used to treat opioid-induced constipation in patients receiving palliative care

Question 8

What laxative acts as an opioid antagonist?

Answer 8

Methylnaltrexone

Question 9

This is a natural plant product, high in fiber, than promotes peristalsis to treat intermittent IBS constipation.

Answer 9

Psyllium

Question 10

What are the indications for use of TNF antagonists in IBD treatment?

Answer 10

Inadequate use to mesalamine and corticosteroids

Question 11

These drugs act as TNF receptor antagonists that inhibit proinflammatory cytokine expression.

Answer 11

Adalimumab, Infiximab

Question 12

What is the MOA of stimulant laxatives?

Answer 12

Triggers contraction and relaxation of the intestine to move along stool more quickly.

Question 13

What anti-diarrheal acts as an anti-integrin that prevents leukocyte binding to selectins and ICAM?

Answer 13

Natalizumab

Question 14

Corticosteroids are used for what

Question 15

What is the MOA of mesalamine?

Answer 15

Inhibits NF-kb to reduce proinflammatory cytokine expression in the treatment of IBD diarrhea

Question 16

This drug is an opioid agonist, but may cross the BBB and cause dependence. A prescription is needed for use.

Answer 16

Diphenoxylate

Question 17

This anti-emetic has some anti-diarrheal effects. What is its MOA?

Answer 17

Metoclopramide - D2 antagonist that increases GI tone and motility

Question 18

What drugs belong to the 5-aminosalicylates class of anti-diarrheal drugs?

Answer 18

Mesalamine, Sulfasalzine

Question 19

What is the clinical use of magnesium hydroxide?

Answer 19

Acute constipation and prevention of chronic constipation

Question 20

What is the MOA of loperamide?

Answer 20

Anti-diarrheal that acts as a mu receptor agonist

Question 21

What is the MOA of drugs indicated to treat IBS-constipation?

Answer 21

Lubiprostone, linaclotide - activate Cl- channels in the small intestine

Question 22

What is the MOA of Psyllium?

Answer 22

Indigestible fiber that absorbs water into the intestine, distends the colon, and promotes peristalsis and evacuation

Question 23

What is generally used as a first-line treatment for mild to moderate IBD?

Answer 23

Mesalamine