Pharmacology of Diarrhea, Constipation, IBS & IBD Agent Flashcards
This class of drugs are used for IBD acute flares.
Corticosteroids (prednisone)
These drugs are indicated to treat IBS-constipation and activate Cl- channels.
Lubiprostone, linaclotide
What is the MOA of Natalizumab?
Anti-integrin that prevents leukocyte binding to vascular endothelium
What are the clinical indications for alosetron?
Women with refractory IBS-diarrhea. Efficacy has not been established in men.
This anti-diarrheal is a 5-HT3 receptor antagonist.
Alosetron
What is the MOA of magnesium hydroxide?
Osmotic agent that increases the water content of stool to treat constipation
True/False. Methylnaltrexone is a first-line anti-diarrheal. for opioid-induced constipation.
False - methylnaltrexone is an opioid antagonist used to treat opioid-induced constipation in patients receiving palliative care
What laxative acts as an opioid antagonist?
Methylnaltrexone
This is a natural plant product, high in fiber, than promotes peristalsis to treat intermittent IBS constipation.
Psyllium
What are the indications for use of TNF antagonists in IBD treatment?
Inadequate use to mesalamine and corticosteroids
These drugs act as TNF receptor antagonists that inhibit proinflammatory cytokine expression.
Adalimumab, Infiximab
What is the MOA of stimulant laxatives?
Triggers contraction and relaxation of the intestine to move along stool more quickly.
What anti-diarrheal acts as an anti-integrin that prevents leukocyte binding to selectins and ICAM?
Natalizumab
Corticosteroids are used for what
What is the MOA of mesalamine?
Inhibits NF-kb to reduce proinflammatory cytokine expression in the treatment of IBD diarrhea
This drug is an opioid agonist, but may cross the BBB and cause dependence. A prescription is needed for use.
Diphenoxylate
This anti-emetic has some anti-diarrheal effects. What is its MOA?
Metoclopramide - D2 antagonist that increases GI tone and motility
What drugs belong to the 5-aminosalicylates class of anti-diarrheal drugs?
Mesalamine, Sulfasalzine
What is the clinical use of magnesium hydroxide?
Acute constipation and prevention of chronic constipation
What is the MOA of loperamide?
Anti-diarrheal that acts as a mu receptor agonist
What is the MOA of drugs indicated to treat IBS-constipation?
Lubiprostone, linaclotide - activate Cl- channels in the small intestine
What is the MOA of Psyllium?
Indigestible fiber that absorbs water into the intestine, distends the colon, and promotes peristalsis and evacuation
What is generally used as a first-line treatment for mild to moderate IBD?
Mesalamine
