Pharmacology of Anxiety Disorders

Question 1

What is the MOA of buspirone?

Answer 1

Interacts with the 5-HT1A receptor

Question 2

This sedative-hypnotic medication is safe for use during pregnancy.

Answer 2

Buspirone

Question 3

For what conditions are benzodiazepines approved for treatment?

Answer 3

Anxiety and panic disorders, sleep onset and maintenance, status epilepticus, alcohol withdrawal, amnesia, muscular disorders

Question 4

This drug can be used to treat overdoses of benzodiazepines, zolpidem, zaleplon, and eszopiclone?

Answer 4

Flumazenil

Question 5

What is the MOA of Suvorexant?

Answer 5

Antagonist of OX1 & OX2 (orexin) receptors

Question 6

These drugs are used to treat insomnia with sleep maintenance issues.

Answer 6

Eszopiclone

Question 7

What is the MOA of ramelteon & tasimelteon?

Answer 7

Activates melatonin receptors

Question 8

What sedative-hypnotic medication is approved only to treat Generalized Anxiety Disorder?

Answer 8

Buspirone

Question 9

These drugs are used to treat insomnia with sleep onset issues.

Answer 9

Zolpidem, Zaleplon, Ramelteon, Tasimelteon, Suvorexant

Question 10

What anti-anxiety medication is an antagonist of OX1R & OX2R?

Answer 10

Suvorexant

Question 11

What anti-anxiety mediation interacts with the 5-HT1A receptor?

Answer 11

Buspirone

Question 12

What is the MOA of benzodiazepines?

Answer 12

Target the GABAa receptor to increase the frequency of opening of Cl- channels.

Question 13

What sedative-hypnotic drug is used for anesthesia?

Answer 13

Thiopental

Question 14

What is the difference between a sedative and a hypnotic?

Answer 14

A sedative is a drug that reduces anxiety and exerts a calming effect. A hypnotic produces drowsiness and encourages sleep.

Question 15

Sedative-hypnotic drugs should be used with caution in these patient populations.

Answer 15

Patients with liver problems and narcolepsy

Question 16

What is the MOA of barbituates?

Answer 16

Target the GABAa receptor to increase the duration of Cl- channel opening.

Question 17

How are sedative-hypnotic drugs metabolized in the body?

Answer 17

They are biotransformed by hepatic enzymes and excreted in the urine.

Question 18

What is the MOA of zolpidem, zaleplon, and eszopiclone?

Answer 18

Target GABAa receptor at the same site as benzodiazepines.

Question 19

What is the clinical effect of ramelteon & tasimelteon?

Answer 19

Decrease latency of sleep onset with minimal withdrawal effects.

Question 20

What anti-anxiety medications activate melatonin receptors?

Answer 20

Ramelteon & Tasimelteon

Question 21

Buspirone is used to treat what condition?

Answer 21

Generalized anxiety disorder

Question 22

For what conditions are benzodiazepines used?

Answer 22

Anesthesia, anti-convulsant

Question 23

What is the clinical effect of suvorexant?

Answer 23

Hypnotic properties used to treat insomnia